The early identification of candidates for epilepsy surgery

作者: Dennis J. Dlugos

DOI: 10.1001/ARCHNEUR.58.10.1543

关键词:

摘要: The effectiveness of resective surgery for the treatment carefully selected patients with medically intractable, localization-related epilepsy is clear. Seizure-free rates following temporal lobectomy are consistently 65% to 70% in adultsand 68% 78% children.Extratemporal resections less commonly lead a seizure-free outcome, although one recent childhood series reported rate 62% extratemporal surgery.With both and resections, additional have reduction seizures but not completely seizure free. identification favorable surgical candidates has been subject extensive research, many investigators examined predictors outcome surgery. However, early potential candidate optimal timing only occasionally addressed literature. This issue methodologically challenging study since studies require large numbers new-onset partial who followed over time. purpose this article review current ability prediction medical intractability surgically remediable epilepsy. Emphasis will be placed on intractable lobe children adolescents, remains prototype surgery, may improve psychosocial younger patients.

参考文章(36)
J R Stevens, Interictal clinical manifestations of complex partial seizures. Advances in Neurology. ,vol. 11, pp. 85- 112 ,(1975)
T. S. Walczak, R. A. Radtke, J. O. McNamara, D. V. Lewis, J. S. Luther, E. Thompson, W. P. Wilson, A. H. Friedman, B. S. Nashold, Anterior temporal lobectomy for complex partial seizures: evaluation, results, and long-term follow-up in 100 cases. Neurology. ,vol. 40, pp. 413- 413 ,(1990) , 10.1212/WNL.40.3_PART_1.413
Guido Hermanns, Soheyl Noachtar, Ingrid Tuxhorn, Hans Holthausen, Alois Ebner, Peter Wolf, Systematic testing of medical intractability for carbamazepine, phenytoin, and phenobarbital or primidone in monotherapy for patients considered for epilepsy surgery. Epilepsia. ,vol. 37, pp. 675- 679 ,(1996) , 10.1111/J.1528-1157.1996.TB00632.X
Richard H Mattson, Joyce A Cramer, Joseph F Collins, None, Prognosis for total control of complex partial and secondarily generalized tonic clonic seizures Neurology. ,vol. 47, pp. 68- 76 ,(1996) , 10.1212/WNL.47.1.68
Patrick Kwan, Martin J. Brodie, Early Identification of Refractory Epilepsy New England Journal of Medicine. ,vol. 342, pp. 314- 319 ,(2000) , 10.1056/NEJM200002033420503
Leonard E. Braitman, Predicting Clinical States in Individual Patients Annals of Internal Medicine. ,vol. 125, pp. 406- 412 ,(1996) , 10.7326/0003-4819-125-5-199609010-00008
Dieter Schmidt, Klaus Richter, Alternative single anticonvulsant drug therapy for refractory epilepsy. Annals of Neurology. ,vol. 19, pp. 85- 87 ,(1986) , 10.1002/ANA.410190118
Peter R. Camfield, Carol S. Camfield, Kevin Gordon, Joseph M. Dooley, If a first antiepileptic drug fails to control a child's epilepsy, what are the chances of success with the next drug?☆☆☆ The Journal of Pediatrics. ,vol. 131, pp. 821- 824 ,(1997) , 10.1016/S0022-3476(97)70027-1
John F. Annegers, W. Allen Hauser, Lila R. Elveback, Remission of seizures and relapse in patients with epilepsy. Epilepsia. ,vol. 20, pp. 729- 737 ,(1979) , 10.1111/J.1528-1157.1979.TB04857.X