Transfusion of white-cell containing allogeneic blood components and postoperative wound infection: effect of confounding factors.

摘要: Randomized controlled trials (RCTs) of the relationship between allogeneic transfusion and post-operative bacterial infection at any site have generated discordant results, but suggested an association with wound infection. To examine specific perioperative infection, we reviewed records 964 consecutive patients undergoing elective colorectal cancer resection our hospital. Diagnoses were made retrospectively by Centers for Disease Control criteria, was defined as number units white-cell containing blood components received. The probability in calculated following adjustment effects 12 confounders that had not been previously considered combination. These factors related to severity illness, difficulty operation risk Wound developed 39 (11.4%) transfused patients, compared 24 (3.9%) untransfused subjects (P < 0.0001). In multivariate analysis, there a trend suggesting adverse effect, which amounted 7% increase per unit red cells or platelets (relative [RR] = 1.07; 95% confidence interval RR 0.98-1.16; P 0.1241). This marginally significant effect 0.1274), rather than 0.3061), transfusion. We conclude may perhaps be associated small this can established only RCTs enrolling several thousand patients. modest magnitude responsible disagreements among published RCTs.