Epidemiologic marker system for Citrobacter diversus using outer membrane protein profiles.

摘要: Investigations of nursery outbreaks Citrobacter diversus sepsis and meningitis have been hampered by lack adequate epidemiologic markers for the organism. We studied outer membrane protein profiles from clinical isolates C. sodium dodecyl sulfate-polyacrylamide gel electrophoresis to determine whether this method might be useful in differentiation strains. Paired cerebrospinal fluid each three separate meningitis, paired vagina a postpartum woman her newborn infant, one isolate an infant with pneumonia two colonized cohorts, 30 epidemiologically unrelated were included. Eleven distinct differentiated presence or absence five proteins. Complete concordance was observed related isolates. Unrelated epidemic strains had another. Biotyping complemented determination profiles; all but nonepidemic Determination is potentially investigations disease caused diversus.