The Risk of Retinopathy of Prematurity in the Infants following Assisted Reproductive Technology: A Meta-Analysis.

摘要: Currently, the use of assisted reproductive technology (ART) is increasing. Because poor prognosis retinopathy prematurity (ROP), association between ART and ROP has been explored in several studies, but result was still inconclusive. Conducting a meta-analysis, we evaluated risk relation to ART. Subgroup analysis as well groups with different embryo numbers stages further analyzed. The PubMed, Embase, Cochrane Library databases were searched for studies recording data about both occurrence simultaneously. Odds ratios (ORs) 95% confidence interval (95%CI) calculated analyze by using random- or fixed-effect models based on heterogeneity test. In total 15 observational containing 10392 cases 39474 spontaneous conception included. Results showed that there significant offspring (OR = 1.34, CI: 1.05 1.73, P 0.02). With subgroup analysis, found influence actually came from ART, vitro fertilization (IVF). Moreover, singletons. Though insignificant, ORs larger than 1 stage 2 ROP. But 3 Our study preliminarily indicated IVF associated higher occurrence. And more likely severe Further specific, high-quality large sample size are needed draw precise conclusion.