Synthesis, spectral and pharmacological studies on lanthanide(III) complexes of 3,5-pyrazoledicarboxylic acid

摘要: Complexes of cerium(III), lanthanum(III) and neodymium(III) with 3,5-pyrazoledicarboxylic acid (H3pdc) were synthesized their compositions determined by elemental analysis. To identify the binding Ce(III), La(III) Nd(III) H3pdc, detailed vibrational analysis was performed comparing experimental spectra ligand its Ln(III) complexes theoretically predicted literature data from related compounds. Significant differences in IR Raman observed as compared to ligand. The tested for cytotoxic activities on chronic myeloid leukemia derived K-562, overexpressing BCR-ABL fusion protein non-Hodgkin lymphoma DOHH-2, characterized an overexpression antiapoptotic bcl-2 cell lines. results indicate that compounds exerted considerable activity upon evaluated lines a concentration dependent manner; we constructe...