Regulation of hemopoiesis in myelosuppressed mice by human recombinant IL-1 alpha.

摘要: Human rIL-1 alpha was shown to be a potent stimulus of granulopoiesis in mice that have been myelosuppressed with cyclophosphamide. Stimulation demonstrated IL-1-treated by an accelerated recovery granulocyte-macrophage colony-forming cells, bone marrow and splenic granulocytic hyperplasia, profound granulocytosis. Granulopoiesis stimulated IL-1 dose-dependent manner at doses ranging from 0.5 50 micrograms/kg. Maximal increases granulocytes were observed after 4 days treatment. Mice treated also exhibited increased megakaryopoiesis resultant increase the number peripheral blood platelets. In contrast these positive effects on hemopoiesis, marrow, but not splenic, erythropoiesis depressed mice. wide dose range (50 300 mg/kg) cyclophosphamide, optimal occurring 200 mg/kg. The leading enhanced caused only minor transient changes selected clinical chemistry parameters no toxicities evident histologic examination tissues. stimulation absence overt toxicity suggests may useful clinically enhance patients.