The therapeutic potential of thyrotropin releasing hormone (TRH) in Alzheimer's disease (AD)

摘要: Abstract 1. In recent years It has been established that patients with AD have a relatively specific loss of cerebral cortical and hippocampal chollnergic nerve terminals. This may be reflection degeneration cholinergic neurons originating the nucleus basalls Meynert septum Which project to cortex hippocampus, respectively. 2. view long-standing association mechanisms cognitive processes recognition selective deficits in AD, therapeutic attempts enhance CNS function undertaken AD. 3. While only limited success this strategy achieved date, use TRH offer novel, yet rational, approach treating assumption is predicated on extensive literature documenting unique, facilltatory interactions peptide throughout neuraxis. 4. Furthermore, same rationale account for recently reported benefit amyotrophic lateral sclerosis, which like disease whose symptoms are manifested through progressive subpopulation neurons.