Skeletal muscle satellite cells: Mediators of muscle growth during development and implications for developmental disorders

摘要: Satellite cells (SCs) are the muscle stem responsible for longitudinal and cross-sectional postnatal growth, repair after injury which provide new myonuclei when needed. Here we review their morphology, contribution to development, role in sarcomere myonuclear addition. SCs, similar other tissue cells, cycle through different states such as quiescence, activation, self-renewal thus consider signaling mechanisms involved maintenance of these states. The SC niche, interactions with fibroblasts extracellular matrix all emerging important factors that affect aging disease. Interestingly, children cerebral palsy appear have a reduced number, could play muscular development even contracture formation. Finally current information on dysfunction dystrophy therapies target promotion myogenesis reduction fibrosis.