Subunit Structure and Regulation of the Insulin-Receptor Complex

摘要: Methods and reagents developed during the late 1970s have led to significant new insights into protein structure of insulin receptor over past five years. The importance this information resides in presumption that initiates all biological responses mediated by hormone therefore its must contain key related cellular signaling mechanisms. Because mechanism action is still not understood, assumption has yet been proved. However, data available are fully consistent with view. Furthermore, it probable receptor, like many other systems, contains structural catalyzes functions such as desensitization response transport or among various compartments, well own recycling from intracellular compartments cell-surface membrane. It seems reasonable assume domains participate both specifically directly these functions. follows an important future objective field obtain primary sequence general order better define biochemical mechanisms which fulfills