Hypertension in renal parenchymal disease: why is it so resistant to treatment?
作者： V.M. Campese , N. Mitra , D. Sandee
关键词:
摘要: The association between hypertension and chronic renal disease is well known. pathogenesis of in patients with kidney (CKD) complex multifactorial, which may explain why it resistant to treatment. traditional paradigm that CKD due either an excess intravascular volume (volume dependent) or excessive activation the renin–angiotensin system relation state sodium/volume balance (renin-dependent hypertension). This review focuses on importance less established mechanisms, such as increased activity sympathetic nervous system, endothelin production, decreased availability endothelium-derived vasodilators structural changes arteries, ischemia, sleep apnea.
kidney-international.org
nature.com
core.ac.uk 
sci-hub.se 参考文章(73)
Nosratola D. Vaziri, Mechanism of erythropoietin-induced hypertension American Journal of Kidney Diseases. ,vol. 33, pp. 821- 828 ,(1999) , 10.1016/S0272-6386(99)70413-0
E Miyajima, Y Yamada, Y Yoshida, T Matsukawa, H Shionoiri, O Tochikubo, M Ishii, Muscle sympathetic nerve activity in renovascular hypertension and primary aldosteronism. Hypertension. ,vol. 17, pp. 1057- 1062 ,(1991) , 10.1161/01.HYP.17.6.1057
Qinghua Hu, Stefano Corda, Jay L. Zweier, Maurizio C. Capogrossi, Roy C. Ziegelstein, Hydrogen Peroxide Induces Intracellular Calcium Oscillations in Human Aortic Endothelial Cells Circulation. ,vol. 97, pp. 268- 275 ,(1998) , 10.1161/01.CIR.97.3.268
F.R. Calaresu, J. Ciriello, Renal afferent nerves affect discharge rate of medullary and hypothalamic single units in the cat Journal of The Autonomic Nervous System. ,vol. 3, pp. 311- 320 ,(1981) , 10.1016/0165-1838(81)90072-2
Nobuhiro Suzuki, Hirokazu Matsumoto, Takashi Miyauchi, Katsutoshi Goto, Tomoh Masaki, Masao Tsuda, Masahiko Fujino, Endothelin-3 concentrations in human plasma: the increased concentrations in patients undergoing haemodialysis. Biochemical and Biophysical Research Communications. ,vol. 169, pp. 809- 815 ,(1990) , 10.1016/0006-291X(90)90403-A
Marianne C. Verhaar, Fiona E. Strachan, David E. Newby, Nicholas L. Cruden, Hein A. Koomans, Ton J. Rabelink, David J. Webb, Endothelin-A Receptor Antagonist–Mediated Vasodilatation Is Attenuated by Inhibition of Nitric Oxide Synthesis and by Endothelin-B Receptor Blockade Circulation. ,vol. 97, pp. 752- 756 ,(1998) , 10.1161/01.CIR.97.8.752
Lacy L. Kolo, Thomas C. Westfall, Heather Macarthur, Nitric oxide decreases the biological activity of norepinephrine resulting in altered vascular tone in the rat mesenteric arterial bed. American Journal of Physiology-heart and Circulatory Physiology. ,vol. 286, ,(2004) , 10.1152/AJPHEART.00668.2003
Richard L. Converse, Tage N. Jacobsen, Robert D. Toto, Charles M.T. Jost, Frank Cosentino, Fetnat Fouad-Tarazi, Ronald G. Victor, Sympathetic overactivity in patients with chronic renal failure. The New England Journal of Medicine. ,vol. 327, pp. 1912- 1918 ,(1992) , 10.1056/NEJM199212313272704
Rhian M. Touyz, Ernesto L. Schiffrin, Increased generation of superoxide by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients: role of phospholipase D-dependent NAD(P)H oxidase-sensitive pathways. Journal of Hypertension. ,vol. 19, pp. 1245- 1254 ,(2001) , 10.1097/00004872-200107000-00009
Jane Goddard, Corine Eckhart, Neil R Johnston, Allan D Cumming, Andrew J Rankin, David J Webb, Endothelin A Receptor Antagonism and Angiotensin-Converting Enzyme Inhibition Are Synergistic via an Endothelin B Receptor-Mediated and Nitric Oxide-Dependent Mechanism Journal of the American Society of Nephrology. ,vol. 15, pp. 2601- 2610 ,(2004) , 10.1097/01.ASN.0000141313.84470.4B