Polymer-modified gadolinium metal-organic framework nanoparticles used as multifunctional nanomedicines for the targeted imaging and treatment of cancer.

摘要: Novel nanoscale theragnostic devices were successfully prepared through attachment of well defined, multifunctional polymer chains to gadolinium (Gd) metal-organic framework (MOF) nanoparticles. Copolymers poly(N-isopropylacrylamide)-co-poly(N-acryloxysuccinimide)-co-poly(fluorescein O-methacrylate) via reversible addition-fragmentation chain transfer (RAFT) polymerization. The succinimide functionality was utilized as a scaffold for both therapeutic agent, such methotrexate, and targeting ligand, H-glycine-arginine-glycine-aspartate-serine-NH(2) peptide. Employment trithiocarbonate RAFT agent allowed reduction the end groups thiolates providing means copolymer vacant orbitals on Gd(3+) ions at surface Gd MOF These versatile, scaffolds shown be biocompatible have cancer cell targeting, bimodal imaging, disease treatment capabilities. This unique method provided simple yet versatile route producing polymer-nanoparticle materials with an unprecedented degree flexibility in construct, potentially allowing tunable loading capacities spatial targeting/treatment agents, while incorporating imaging capabilities magnetic resonance fluorescence microscopy.