Visceral pain perception is determined by the duration of colitis and associated neuropeptide expression in the mouse

摘要: Background: Even though inflammation is a traditional tool for the induction of hyperalgesia in many tissues, recent observations suggest that not all inflammatory processes produce this change. Tolerance to colorectal distension (CRD) reduced patients with acute ulcerative colitis but increased chronic bowel disease. This suggests nature infiltrate influences visceral perception. Aim: To test hypothesis by assessing responses CRD mice mild, or colitis. Methods: were measured mild non-specific colitis, and dextran sodium sulphate (DSS)-induced Responses compared tissue damage, interleukin (IL)1β myeloperoxidase (MPO) activity substance P, β-endorphin μ opioid receptor (MOR) expression. Results: Mild associated responsiveness CRD. In contrast, difference was due altered colonic wall compliance. MPO IL1β levels greater than Larger increases P seen DSS, whereas CD4 T cells, MOR expression evident only An inverse correlation between these tissues. Conclusions: Acute accompanied an P. Chronic DSS increase expression, no change compliance responses. We conclude generates hyperalgesia, involves infiltration lymphocytes up regulation, provides antinociceptive input restores normal