Polymorphism - 116C/G of the human X box binding protein 1 gene is associated with risk of type 2 diabetes in a Chinese Han population.
作者： Shengyuan Liu , Guoda Ma , Songpo Yao , Zhongwei Chen , Changyi Wang
DOI: 10.1016/J.GENE.2015.08.037
关键词:
摘要: Abstract Evidence has been obtained showing that endoplasmic reticulum (ER) stress is closely associated with the development of type 2 diabetes (T2D) and human X box binding protein 1 (XBP1) an important transcription factor involved in ER stress. The study aimed to analyze potential association between polymorphism − 116C/G XBP1 risk T2D. T2D was assessed among 1058 consecutive unrelated subjects, including 523 patients 535 healthy controls, a case control study. − 116GG genotype − 116G allele were more frequent subjects compared by statistical analysis, homozygote might lead increased susceptibility Chinese Han population. had higher fasting plasma glucose levels, insulin HbA1c worse HOMA-IR than − 116CG − 116CC genotypes (P
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sci-hub.se 参考文章(18)
S. Oyadomari, E. Araki, M. Mori, Endoplasmic reticulum stress-mediated apoptosis in pancreatic β-cells Apoptosis. ,vol. 7, pp. 335- 345 ,(2002) , 10.1023/A:1016175429877
Rungtawan Sriburi, Suzanne Jackowski, Kazutoshi Mori, Joseph W. Brewer, XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum Journal of Cell Biology. ,vol. 167, pp. 35- 41 ,(2004) , 10.1083/JCB.200406136
Umut Ozcan, Qiong Cao, Erkan Yilmaz, Ann-Hwee Lee, Neal N Iwakoshi, Esra Ozdelen, Gurol Tuncman, Cem Görgün, Laurie H Glimcher, Gokhan S Hotamisligil, Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes Science. ,vol. 306, pp. 457- 461 ,(2004) , 10.1126/SCIENCE.1103160
Yunqing Ren, Sen Yang, Shengxin Xu, Min Gao, Wei Huang, Tianwen Gao, Qiaoyun Fang, Cheng Quan, Chi Zhang, Liangdan Sun, Yanhua Liang, Jianwen Han, Zhimin Wang, Fengyu Zhang, Youwen Zhou, Jianjun Liu, Xuejun Zhang, Genetic Variation of Promoter Sequence Modulates XBP1 Expression and Genetic Risk for Vitiligo PLOS Genetics. ,vol. 5, ,(2009) , 10.1371/JOURNAL.PGEN.1000523
H. Liou, M. Boothby, P. Finn, R Davidon, N Nabavi, N. Zeleznik-Le, J. Ting, L. Glimcher, A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter Science. ,vol. 247, pp. 1581- 1584 ,(1990) , 10.1126/SCIENCE.2321018
Eiichi Araki, Tomomi Gotoh, Akio Koizumi, Seiichi Oyadomari, Kiyoshi Takeda, Shizuo Akira, Masataka Mori, Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes Journal of Clinical Investigation. ,vol. 109, pp. 525- 532 ,(2002) , 10.1172/JCI14550
F. Filipponi, G. C. Weir, D. L. Eizirik, M. Cnop, P. Marchetti, M. Bugliani, R. Lupi, L. Marselli, M. Masini, U. Boggi, The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients. Diabetologia. ,vol. 50, pp. 2486- 2494 ,(2007) , 10.1007/S00125-007-0816-8
Takuya Masui, Ryota Hashimoto, Ichiro Kusumi, Katsuji Suzuki, Teruaki Tanaka, Shin Nakagawa, Hiroshi Kunugi, Tsukasa Koyama, A possible association between the -116C/G single nucleotide polymorphism of the XBP1 gene and lithium prophylaxis in bipolar disorder. The International Journal of Neuropsychopharmacology. ,vol. 9, pp. 83- 88 ,(2005) , 10.1017/S1461145705005523
Hiderou Yoshida, Masaya Oku, Mie Suzuki, Kazutoshi Mori, pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response. Journal of Cell Biology. ,vol. 172, pp. 565- 575 ,(2006) , 10.1083/JCB.200508145
D. R. Laybutt, A. M. Preston, M. C. Åkerfeldt, J. G. Kench, A. K. Busch, A. V. Biankin, T. J. Biden, Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes. Diabetologia. ,vol. 50, pp. 752- 763 ,(2007) , 10.1007/S00125-006-0590-Z