Radiation therapy impairs endothelium-dependent vasodilation in humans
作者： Joshua A Beckman , Avni Thakore , Barbara H Kalinowski , Jay R Harris , Mark A Creager
DOI: 10.1016/S0735-1097(00)01190-6
关键词:
摘要: OBJECTIVES The objective of this study was to test the hypothesis that external-beam radiation induces a chronic impairment endothelium-dependent vasodilation. BACKGROUND Radiation therapy is used commonly in treatment cancer and associated with an increased incidence adverse vascular events related field radiation, including stroke myocardial infarction. As endothelial injury central pathogenesis diseases, we hypothesized radiotherapy arterial dysfunction. METHODS Sixteen women unilateral breast who underwent standard axilla >3 years before enrollment ten healthy were studied. Vascular ultrasonography image both artery exposed contralateral artery. Flow-mediated, vasodilation endothelium-independent nitroglycerin axillary arteries measured. RESULTS Endothelium-dependent significantly impaired irradiated compared contralateral, nonirradiated (−0.4 ± 0.4% vs. 3.2 0.8%, p < 0.001) also control subjects’ 2.5 0.6%, 0.001). In contrast, greater received (3.8 0.5% 2.0 0.4%, 0.05) 0.05). CONCLUSIONS External beam impairs conduit arteries, implicating decrease bioavailability nitric oxide. These abnormalities may contribute development occlusive disease clinical events.
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