The molecular epidemiology of HIV-1 in the Comunidad Valenciana (Spain): analysis of transmission clusters

摘要: HIV infections are still a very serious concern for public heath worldwide. We have applied molecular evolution methods to study the HIV-1 epidemics in Comunidad Valenciana (CV, Spain) from health surveillance perspective. For this, we analysed 1804 sequences comprising protease and reverse transcriptase (PR/RT) coding regions, sampled between 2004 2014. These were subtyped subjected phylogenetic analyses order detect transmission clusters. In addition, univariate multinomial comparisons performed epidemiological differences subtypes, risk groups. The epidemic CV is dominated by subtype B among local men who sex with (MSM). 270 clusters identified (>57% of dataset), 12 which included ≥10 patients; 11 (9 affecting MSMs) one (n = 21) CRF14, predominately intravenous drug users (IDUs). Dated phylogenies revealed these large originated mid-80s early 00 s. Subtype more likely form than non-B variants MSMs cluster other Multinomial an association variants, not established population yet, different foreign