The SH2 Domain: A Prototype for Protein Interaction Modules
作者： Tony Pawson , Gerald D. Gish , Piers Nash
DOI: 10.1002/9783527610754.PP08
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摘要: Originally published in: Modular Protein Domains. Edited by Giovanni Cesareni, Mario Gimona, Marius Sudol and Michael Yaffe. Copyright © 2005 Wiley-VCH Verlag GmbH & Co. KGaA Weinheim. Print ISBN: 3-527-30813-2 The sections in this article are The Multidomain Nature of Signaling Proteins Identification the SH2 Domain SH2 Domains as a Prototype for Interaction Domains Structure Binding Properties Domains Different Modes Domain-Phosphopeptide Recognition Signaling Pathways Networks Plasticity Domains SH2 Domain Dimerization Tandem Domains Composite Complex Domains Allosteric Regulation SH2 Disease Conclusions Keywords: Modular protein domains; adaptors; SH2 domain; prototype interaction domains; multidomain nature; signaling proteins; structure binding properties; phosphopeptide recognition; signaling pathways; signaling networks; tandem domains; allosteric regulation; SH2 domains disease
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