Sixteen years of evolution of human respiratory syncytial virus subgroup A in Buenos Aires, Argentina: GA2 the prevalent genotype through the years.

摘要: Human respiratory syncytial virus (HRSV) is the main viral cause of acute lower tract infections (LRTI) in children worldwide. In recent years, several preclinical trials with vaccine candidates have been reported. It this sense that molecular epidemiological studies become important. Understanding dispersion patterns before and after implementation a can provide insight into effectiveness control strategies. work we analyzed epidemiology HRSV-A over period sixteen years (1999-2014) Buenos Aires. By bioinformatic tools 169 sequences G glycoprotein gene from hospitalized pediatric patients LRTI. We found GA2 was most prevalent genotype (73.35%). GA5 co-circulated our region until 2009 when it no longer detected, except 2011. The recently globally emerging ON1 lineage 72-nt duplication increased its frequency to only detected Aires 2014. discrete phylogeographic analysis global strains could determine Panama be location MRCA dated June 20, 2010; introduced Argentina Spain April This also showed temporary geographical clustering observed as phylogenetic clades exclusively associated single country, nevertheless among 44 three outbreaks (2012-2014) detect posterior reintroductions circulation United States, Cuba, South Korea, Spain. continuous one sublineage Argentine allowed us establish there local some even neighborhoods. shows potential type context future surveillance network trace spread new genetic lineages human populations.