Chirality as a tool in nucleic acid recognition: principles and relevance in biotechnology and in medicinal chemistry.

摘要: The understanding of the interaction chiral species with DNA or RNA is very important for development new tools in biology and drugs. Several cases which chirality a crucial point determining binding mode are reviewed discussed, aim illustrating how can be considered as tool improving mechanisms effectiveness nucleic acid recognition. review divided into two parts: former describes examples interacting DNA: intercalators, metal complexes, groove binders; latter part dedicated to analogs, discussion phosphate stereochemistry ribose substitutes, particular peptide acids (PNAs) number works have been published recently dealing effect intended show enantiomeric recognition originates at molecular level, by exploiting enormous progresses achieved field structural characterization complexes formed their ligands crystallographic spectroscopic methods. Examples application molecules described role relevant biotechnology medicinal chemistry reported.