Assessment of cardiovascular autonomic function in patients with polycystic ovary syndrome
作者： Kuppusamy Saranya , Gopal Krushna Pal , Syed Habeebullah , Pravati Pal
DOI: 10.1111/JOG.12154
关键词:
摘要: Aim The study was conducted to assess the sympathovagal balance in patients with polycystic ovary syndrome (PCOS) using short-term heart rate variability (HRV) analysis and conventional autonomic function tests (CAFT). Methods Thirty-one newly diagnosed PCOS 30 age-matched controls were recruited. Body mass index (BMI), waist : hip ratio (WHR), cardiovascular parameters such as basal (BHR), systolic blood pressure (SBP), diastolic (DBP) rate-pressure product (RPP), fasting glucose (FBG) measured both groups. Cardiovascular functions assessed spectral of HRV, response standing (30:15 ratio), deep breathing (E:I ratio) isometric handgrip (ΔDBP(ihg)). Results cases had significantly increased BMI, WHR, BHR, SBP, DBP RPP. Ratio low-frequency high-frequency power HRV (LF-HF marker compared controls. Time-domain indices E:I decreased, 30:15 ratio, ΔDBP(ihg) FBG cases. Though there a significant correlation LF-HF RPP FBG, only BHR independent contribution ratio. Conclusion We conclude that have altered modulation form sympathetic decreased parasympathetic reactivity HRV. imbalance exposes them morbidities.
sci-hub.se 参考文章(22)
Phillip A. Low, Chapter 36 Laboratory evaluation of autonomic function Advances in Clinical Neurophysiology, Proceedings of the 27th International Congress of Clinical Neurophysiology, AAEM 50th Anniversary and 57th Annual Meeting of the ACNS Joint Meeting. ,vol. 57, pp. 358- 368 ,(2004) , 10.1016/S1567-424X(09)70372-1
Enrico Carmina, Obesity, Adipokines and Metabolic Syndrome in Polycystic Ovary Syndrome Frontiers of Hormone Research. ,vol. 40, pp. 40- 50 ,(2013) , 10.1159/000341840
Seema Gulati, J S Wasir, Shashank R Joshi, B M Makkar, Y P Munjal, R Gupta, P Chowbey, A Misra, N K Vikram, S Sadikot, D Chadha, Consensus statement for diagnosis of obesity, abdominal obesity and the metabolic syndrome for Asian Indians and recommendations for physical activity, medical and surgical management. Journal of Association of Physicians of India. ,vol. 57, pp. 163- 170 ,(2009)
W WHITE, Heart rate and the rate-pressure product as determinants of cardiovascular risk in patients with hypertension American Journal of Hypertension. ,vol. 12, pp. 2- 4 ,(1998) , 10.1016/S0895-7061(98)00280-5
Christine Perret-Guillaume, Laure Joly, Athanase Benetos, Heart rate as a risk factor for cardiovascular disease. Progress in Cardiovascular Diseases. ,vol. 52, pp. 6- 10 ,(2009) , 10.1016/J.PCAD.2009.05.003
Aylin Yildirir, Funda Aybar, Giray Kabakci, Hakan Yarali, Ali Oto, Heart rate variability in young women with polycystic ovary syndrome Annals of Noninvasive Electrocardiology. ,vol. 11, pp. 306- 312 ,(2006) , 10.1111/J.1542-474X.2006.00122.X
F L Gobel, L A Norstrom, R R Nelson, C R Jorgensen, Y Wang, The rate-pressure product as an index of myocardial oxygen consumption during exercise in patients with angina pectoris. Circulation. ,vol. 57, pp. 549- 556 ,(1978) , 10.1161/01.CIR.57.3.549
Kristen Farrell, Michael H. Antoni, Insulin resistance, obesity, inflammation, and depression in polycystic ovary syndrome: biobehavioral mechanisms and interventions Fertility and Sterility. ,vol. 94, pp. 1565- 1574 ,(2010) , 10.1016/J.FERTNSTERT.2010.03.081
Andrea Dunaif, Hyperandrogenic anovulation (PCOS): A unique disorder of insulin action associated with an increased risk of non-insulin-dependent diabetes mellitus The American Journal of Medicine. ,vol. 98, pp. S33- S39 ,(1995) , 10.1016/S0002-9343(99)80057-6
Roy Freeman, Assessment of cardiovascular autonomic function. Clinical Neurophysiology. ,vol. 117, pp. 716- 730 ,(2006) , 10.1016/J.CLINPH.2005.09.027