Characteristics of Drug-Induced Liver Injury in Northeast China: Disease Spectrum and Drug Types.
作者： Chong Zhang , Yuyu Wu , Suyu Yuan , Xiaoguang Dou , Qiuju Sheng
DOI: 10.1007/S10620-019-06030-6
关键词:
摘要: The aim of this study was to determine the disease spectrum and drug types causing drug-induced liver injury (DILI) in northeast China, so that affected population can be reminded need increase their post-medication monitoring. A total 470 DILI patients hospitalized at Shengjing Hospital between 2013 2016 were involved retrospective study. There significant differences different age groups (P 10% all drugs caused DILI. percentage DILIs related Chinese herbal medicines (CHMs) gradually increased with patient (P = 0.002). males taking health supplements or CHMs significantly lower compared females. Total bilirubin (β = 0.01, OR = 1.01, P < 0.001) INR (β = 0.74, OR = 2.11, found independent predictors damage. main type causes China is a CHM. are ages gender. Making appropriate changes drug-taking habits high-risk used treat underlying diseases, as well increasing monitoring, may help reduce incidence DILIs.
springer.com
sci-hub.se 参考文章(27)
Criteria of drug-induced liver disorders. Report of an international consensus meeting. Journal of Hepatology. ,vol. 11, pp. 272- 276 ,(1990) , 10.1016/0168-8278(90)90124-A
R ANDRADE, M LUCENA, M FERNANDEZ, G PELAEZ, K PACHKORIA, E GARCIARUIZ, B GARCIAMUNOZ, R GONZALEZGRANDE, A PIZARRO, J DURAN, Drug-Induced Liver Injury: An Analysis of 461 Incidences Submitted to the Spanish Registry Over a 10-Year Period Gastroenterology. ,vol. 129, pp. 512- 521 ,(2005) , 10.1016/J.GASTRO.2005.05.006
William M. Lee, Recent developments in acute liver failure. Best Practice & Research in Clinical Gastroenterology. ,vol. 26, pp. 3- 16 ,(2012) , 10.1016/J.BPG.2012.01.014
Einar S Björnsson, Ottar M Bergmann, Helgi K Björnsson, Runar B Kvaran, Sigurdur Olafsson, None, Incidence, Presentation, and Outcomes in Patients With Drug-Induced Liver Injury in the General Population of Iceland Gastroenterology. ,vol. 144, pp. 1419- 1425 ,(2013) , 10.1053/J.GASTRO.2013.02.006
Catherine Sgro, François Clinard, Kader Ouazir, Henry Chanay, Christian Allard, Christian Guilleminet, Claude Lenoir, Alain Lemoine, Patrick Hillon, Incidence of drug-induced hepatic injuries: a French population-based study. Hepatology. ,vol. 36, pp. 451- 455 ,(2002) , 10.1053/JHEP.2002.34857
Jay H. Hoofnagle, Jose Serrano, James E. Knoben, Victor J. Navarro, LiverTox: a website on drug-induced liver injury. Hepatology. ,vol. 57, pp. 873- 874 ,(2013) , 10.1002/HEP.26175
Joonhee Cho, Lina Kim, Zhaoxia Li, Noel R. Rose, Monica Vladut Talor, Dolores B. Njoku, Sex Bias in Experimental Immune-Mediated, Drug-Induced Liver Injury in BALB/c Mice: Suggested Roles for Tregs, Estrogen, and IL-6 PLOS ONE. ,vol. 8, ,(2013) , 10.1371/JOURNAL.PONE.0061186
Robert J Fontana, Paul H Hayashi, Jiezhun Gu, K Rajender Reddy, Huiman Barnhart, Paul B Watkins, Jose Serrano, William M Lee, Naga Chalasani, Andrew Stolz, Timothy Davern, Jayant A Talwakar, DILIN Network, Idiosyncratic Drug-Induced Liver Injury Is Associated With Substantial Morbidity and Mortality Within 6 Months From Onset Gastroenterology. ,vol. 147, pp. 96- 108 ,(2014) , 10.1053/J.GASTRO.2014.03.045
William Bernal, Anna Hyyrylainen, Amit Gera, Vinod K. Audimoolam, Mark J.W. McPhail, Georg Auzinger, Mohammed Rela, Nigel Heaton, John G. O’Grady, Julia Wendon, Roger Williams, Lessons from look-back in acute liver failure? A single centre experience of 3300 patients. Journal of Hepatology. ,vol. 59, pp. 74- 80 ,(2013) , 10.1016/J.JHEP.2013.02.010
Pan Zhao, Chunya Wang, Weiwei Liu, Gang Chen, Xinying Liu, Xi Wang, Bao Wang, Liming Yu, Yanrong Sun, Xiaoming Liang, Haozhen Yang, Fei Zhang, Causes and Outcomes of Acute Liver Failure in China PLoS ONE. ,vol. 8, pp. e80991- ,(2013) , 10.1371/JOURNAL.PONE.0080991