Modélisation mathématique multi-échelle de l'angiogenèse tumorale : analyse de la réponse tumorale aux traitements anti-angiogéniques
作者： Frédérique Billy
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摘要: Le cancer est l'une des principales causes de deces dans le monde. L'angiogenese tumorale processus formation nouveaux vaisseaux sanguins a partir preexistants. Une tumeur cancereuse peut induire l'angiogenese afin disposer d'apports supplementaires en oxygene et nutriments, indispensables la poursuite son developpement. Cette these consiste l'elaboration d'un modele mathematique multi-echelle tumorale. Ce integre les principaux mecanismes intervenant aux echelles tissulaire moleculaire. Couple un croissance tumorale, notre permet d'etudier effets l'apport sur D'un point vue mathematique, ces modeles d'angiogenese reposent equations derivees partielles reaction-diffusion d'advection regissant l'evolution spatio-temporelle densites cellules endotheliales, constituant paroi sanguins, tumorales, ainsi que celle concentrations tissulaires substances pro- antiangiogeniques oxygene. A l'echelle moleculaire, liaison angiogeniques recepteurs membranaires mecanisme cle communication intercellulaire, modelisee l'aide lois pharmacologiques. reproduire in silico d'analyser leur role Il egalement simuler l'action differentes therapies anti-angiogeniques, efficacite developpement tumoral d'aider l'innovation therapeutique
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