Expression of tumor necrosis factor-α in regenerating muscle fibers in inflammatory and non-inflammatory myopathies
作者： Satoshi Kuru , Akira Inukai , Takashi Kato , Yideng Liang , Seigo Kimura
DOI: 10.1007/S00401-002-0635-4
关键词:
摘要: The expression level of tumor necrosis factor (TNF)-α is elevated in idiopathic inflammatory myopathies and Duchenne muscular dystrophy (DMD), but the precise role TNF-α unknown. To elucidate possible TNF-α, we investigated its receptor polymyositis (PM), dermatomyositis (DM), DMD using situ hybridization (ISH) immunohistochemistry. We showed that mRNA protein were present muscle fibers. TNF-α-positive fibers observed all cases PM, DM DMD, rare or absent neurogenic disorders normal controls. proportion fiber a significant positive correlation with regenerating for developmental form myosin heavy chain (MHC-d). number TNF receptor-positive was small. Some expressed both simultaneously. Our results indicate produced by associated regeneration.
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