Cytokines in muscle damage

摘要: Multiple cellular and molecular processes are rapidly activated following skeletal muscle damage to restore normal structure function. These typically involve an inflammatory response potentially the consequent occurrence of secondary before their resolution completion repair or regeneration. The overall outcome process is divergent, with induction prolonged inflammation further damage, its active termination promotion final, detrimental, beneficial effect on influenced by specific interactions between cell-derived cytokines that act as positive and/or negative regulators coordinate local systemic inflammatory-related events modulate process. A crucial balance proinflammatory anti-inflammatory appears attenuate excessive reaction, prevent development fibrosis, adequately promote regenerative In this review, we address interactive cytokine responses in context progression, repair.