Fiber type specific expression of TNF-alpha, IL-6 and IL-18 in human skeletal muscles.
作者： Milena Penkowa , Peter Plomgaard , Bente K Pedersen
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摘要: Skeletal muscle is now recognized as an endocrine organ with the capacity to produce signal peptides in response contractions. Here we demonstrate that resting healthy human muscles express cytokines a fiber type specific manner. Human biopsies from seven young males were obtained m. triceps, quadriceps vastus lateralis and soleus. Type I fibers contributed (mean +/- SE) 24.0 2.5% triceps of total fibers, 51.3 2.4% 84.9 22% As expected, differences composition accompanied by marked between three regard MHC IIa mRNA expression. Immunohistochemistry demonstrated tumor necrosis factor (TNF)-alpha interleukin (IL)-18 solely expressed II whereas expression IL-6 was more prominent compared fibers. The specificity found soleus indicating level daily activity did not influence basal cytokine different types suggests may play regulatory roles normal physiology.
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