Heparin-Like Glycosaminoglycans Inhibit Leukocyte Adhesion to Endotoxin-Activated Human Vascular Endothelial Cells under Nonstatic Conditions

摘要: Since heparin-like glycosaminoglycans (GAGs) have been reported to possess anti-inflammatory effects, we tested effects of GAGs on cell adhesion between endothelial cells (ECs) and leukocytes. Effects molecule expression leukocyte were analyzed using cultured human umbilical vein ECs stimulated by endotoxin. Expression molecules was unchanged, but adherence leukocytes significantly reduced under nonstatic conditions. These results suggest that may act as agents partly inhibition conditions prevent critical caused