Contribution of host resistance to radiosensitivity of an isologous murine lymphoma in vivo.

摘要: SummaryLSA ascites lymphoma cells were irradiated in vitro and assayed vivo isologous recipients. Results with the TD50 method correlated a separate assay using an inoculum containing fixed total number of tumour measuring 50 per cent sterilization dose (SD50) x-radiation. Comparison sham- pre-irradiated recipients showed differences which consistent presence isoantigenic antigens, SD50 method. Host-resistance against was reduced by irradiation recipients, but significant only evident when cell inocula large. Isologous resistance found to become progressively greater significance larger numbers radiation-killed cells. factors appear increase apparent shoulder size (or extrapolation number), decrease D0, convert linear exponential survival curve more parabolic one. may contribute cell-survival response with...