New functional families (FunFams) in CATH to improve the mapping of conserved functional sites to 3D structures
作者： Ian Sillitoe , Alison L. Cuff , Benoit H. Dessailly , Natalie L. Dawson , Nicholas Furnham
DOI: 10.1093/NAR/GKS1211
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摘要: CATH version 3.5 (Class, Architecture, Topology, Homology, available at http://www.cathdb.info/) contains 173 536 domains, 2626 homologous superfamilies and 1313 fold groups. When focusing on structural genomics (SG) structures, we observe that the number of new folds for v3.5 is slightly less than previous releases, this observation suggests may now know majority are easily accessible to structure determination. We have improved accuracy our functional family (FunFams) sub-classification method sequence domain search facility has been extended provide FunFam annotations each domain. The website redesigned. display data conserved features associated with FunFams within superfamily.
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