In vivo delivery, pharmacokinetics, biodistribution and toxicity of iron oxide nanoparticles

作者: Hamed Arami , Amit Khandhar , Denny Liggitt , Kannan M. Krishnan

DOI: 10.1039/C5CS00541H

关键词:

摘要: Iron oxide nanoparticles (IONPs) have been extensively used during the last two decades, either as effective bio-imaging contrast agents or as carriers of biomolecules such as drugs …

参考文章(355)
Ryan Hufschmid, Hamed Arami, R. Matthew Ferguson, Marcela Gonzales, Eric Teeman, Lucien N. Brush, Nigel D. Browning, Kannan M. Krishnan, Synthesis of phase-pure and monodisperse iron oxide nanoparticles by thermal decomposition Nanoscale. ,vol. 7, pp. 11142- 11154 ,(2015) , 10.1039/C5NR01651G
Nasser Arsalani, Hassan Fattahi, Sophie Laurent, Carmen Burtea, Luce Vander Elst, Robert N. Muller, Polyglycerol-grafted superparamagnetic iron oxide nanoparticles: highly efficient MRI contrast agent for liver and kidney imaging and potential scaffold for cellular and molecular imaging. Contrast Media & Molecular Imaging. ,vol. 7, pp. 185- 194 ,(2012) , 10.1002/CMMI.479
Nina Raabe, Evelyn Forberich, Barbara Freund, Oliver T. Bruns, Markus Heine, Michael G. Kaul, Ulrich Tromsdorf, Lena Herich, Peter Nielsen, Rudolph Reimer, Heinrich Hohenberg, Horst Weller, U. Schumacher, Gerhard Adam, Harald Ittrich, Determination of liver-specific r2 * of a highly monodisperse USPIO by (59) Fe iron core-labeling in mice at 3 T MRI. Contrast Media & Molecular Imaging. ,vol. 10, pp. 153- 162 ,(2015) , 10.1002/CMMI.1612
Chen Fang, Narayan Bhattarai, Conroy Sun, Miqin Zhang, Functionalized nanoparticles with long-term stability in biological media. Small. ,vol. 5, pp. 1637- 1641 ,(2009) , 10.1002/SMLL.200801647
Ganesh Venkatraman, Ramya, Shruthilaya, Akila, Ganga, Suresh Kumar, Yoganathan, Roy Santosham, Ponraju, Nanomedicine: towards development of patient-friendly drug-delivery systems for oncological applications. International Journal of Nanomedicine. ,vol. 7, pp. 1043- 1060 ,(2012) , 10.2147/IJN.S25182
Jung‐Taek Kwon, Dae‐Seong Kim, Arash Minai‐Tehrani, Soon‐Kyung Hwang, Seung‐Hee Chang, Eun‐Sun Lee, Cheng‐Xiong Xu, Hwang Tae Lim, Ji‐Eun Kim, Byung‐Il Yoon, Gil‐Hwan An, Kee‐Ho Lee, Jin‐Kyu Lee, Myung‐Haing Cho, Inhaled fluorescent magnetic nanoparticles induced extramedullary hematopoiesis in the spleen of mice. Journal of Occupational Health. ,vol. 51, pp. 423- 431 ,(2009) , 10.1539/JOH.L8159
Huan Xu, Liang Cheng, Chao Wang, Xinxing Ma, Yonggang Li, Zhuang Liu, Polymer encapsulated upconversion nanoparticle/iron oxide nanocomposites for multimodal imaging and magnetic targeted drug delivery Biomaterials. ,vol. 32, pp. 9364- 9373 ,(2011) , 10.1016/J.BIOMATERIALS.2011.08.053
Veronica I. Shubayev, Thomas R. Pisanic, Sungho Jin, Magnetic nanoparticles for theragnostics Advanced Drug Delivery Reviews. ,vol. 61, pp. 467- 477 ,(2009) , 10.1016/J.ADDR.2009.03.007
Qi Yang, Stephen W. Jones, Christina L. Parker, William C. Zamboni, James E. Bear, Samuel K. Lai, Evading immune cell uptake and clearance requires PEG grafting at densities substantially exceeding the minimum for brush conformation Molecular Pharmaceutics. ,vol. 11, pp. 1250- 1258 ,(2014) , 10.1021/MP400703D
Michael Goldberg, Isabel Gomez-Orellana, Challenges for the oral delivery of macromolecules. Nature Reviews Drug Discovery. ,vol. 2, pp. 289- 295 ,(2003) , 10.1038/NRD1067