Simple, Multicomponent, Ecofriendly, Microwave-Mediated Route for the Synthesis of Antimicrobial 2-Amino-6-aryl-4-(3H)-pyrimidinones
作者： Ivangela E. A. da Silva , Vanildo M. L. Braga , Mychely S. Melo , Maria Tereza dos S. Correia , Janaína V. dos Anjos
DOI: 10.1080/00397911.2013.807517
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摘要: Abstract In this work, we describe a multicomponent microwave-mediated synthesis of 10 2-amino-6-aryl-4-oxo-1,6-dihydro-pyrimidine-5-carbonitriles in good chemical yields (44–67%), four them not related earlier literature. All pyrimidinones synthesized herein had their antimicrobial activity evaluated against the following microorganisms: Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. Two substances displayed P. aeruginosa S. aureus, two bacteria responsible for nosocomial infections. [Supplementary materials are available article. Go to publisher's online edition Synthetic Communications® free supplemental resource(s): Full experimental spectral details.]
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