The effect of acute hyperglycemia on the plasma C-peptide response to intravenous glucagon or to a mixed meal in insulin-dependent diabetes mellitus.

摘要: The dose-response relationships between prestimulatory blood glucose concentration and the plasma C-peptide responses to stimulation with 1 mg of glucagon iv or a standard mixed meal were studied in 8 positive patients insulin-dependent diabetes mellitus. Hyperglycemia was maintained for 90 min before using hyperglycemic clamp technique. Each test performed at steady state levels approximately 5, 12, 20 mmol/l. potentiation incremental area under curve two hyperglycemia percent normoglycemia (median range) 343% (53-1053) (p less than 0.05) 341% (267-1027) after 140% (76-227) (NS) 251% (95-1700) meal. corresponding relative 6 124% (100-427) 0.02) 144% (100-209) 0.05). There no significant difference degree 12 Furthermore, there different estimated values B-cell function. In conclusion, markedly potentiated by acute No further was, however, obtained when raised above mmol/l.(ABSTRACT TRUNCATED AT 250 WORDS)