Recruitment of ATR‐ATRIP, Rad17, and 9‐1‐1 Complexes to DNA Damage
作者： Xiaohong Helena Yang , Lee Zou
DOI: 10.1016/S0076-6879(05)09007-5
关键词:
摘要: The ATR (ataxia-telangiectasia mutated and rad3-related)-ATRIP (ATR-interacting protein) kinase complex plays a central role in the checkpoint responses to variety of types DNA damage, especially those interfering with replication. checkpoint-signaling pathway activated by ATR-ATRIP regulates coordinates cell-cycle progression, replication, repair, many other cellular processes critical for genomic stability. Upon damage or replication interference, two its key regulators, Rad17 9-1-1 complexes, are localized sites stalled forks. Recent biochemical cell biological studies have revealed that RPA-coated single-stranded DNA, common structure generated at forks, crucial roles recruitment ATR-ATRIP, Rad17, complexes. regulators is step recognition checkpoint, likely important regulation activity and/or function response damage. methods used characterize association complexes laid foundation further studies, which may ultimately lead us understand molecular mechanisms monitors protects integrity.
elsevier.com
sci-hub.se 参考文章(31)
Yasushi Shiomi, Ayako Shinozaki, Daisuke Nakada, Katsunori Sugimoto, Jiro Usukura, Chikashi Obuse, Toshiki Tsurimoto, Clamp and clamp loader structures of the human checkpoint protein complexes, Rad9-1-1 and Rad17-RFC Genes to Cells. ,vol. 7, pp. 861- 868 ,(2002) , 10.1046/J.1365-2443.2002.00566.X
David Cortez, Saritha Guntuku, Jun Qin, Stephen J Elledge, ATR and ATRIP: Partners in Checkpoint Signaling Science. ,vol. 294, pp. 1713- 1716 ,(2001) , 10.1126/SCIENCE.1065521
Zhongsheng You, Lindsay Kong, John Newport, The Role of Single-stranded DNA and Polymerase α in Establishing the ATR, Hus1 DNA Replication Checkpoint Journal of Biological Chemistry. ,vol. 277, pp. 27088- 27093 ,(2002) , 10.1074/JBC.M204120200
Michael Lisby, Jacqueline H. Barlow, Rebecca C. Burgess, Rodney Rothstein, Choreography of the DNA damage response: Spatiotemporal relationships among checkpoint and repair proteins Cell. ,vol. 118, pp. 699- 713 ,(2004) , 10.1016/J.CELL.2004.08.015
Vincenzo Costanzo, David Shechter, Patrick J Lupardus, Karlene A Cimprich, Max Gottesman, Jean Gautier, An ATR- and Cdc7-Dependent DNA Damage Checkpoint that Inhibits Initiation of DNA Replication Molecular Cell. ,vol. 11, pp. 203- 213 ,(2003) , 10.1016/S1097-2765(02)00799-2
S. M. Post, The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase Nucleic Acids Research. ,vol. 31, pp. 5568- 5575 ,(2003) , 10.1093/NAR/GKG765
K. Unsal-Kacmaz, A. M. Makhov, J. D. Griffith, A. Sancar, Preferential binding of ATR protein to UV-damaged DNA. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 6673- 6678 ,(2002) , 10.1073/PNAS.102167799
J. Majka, P. M. J. Burgers, Yeast Rad17/Mec3/Ddc1: A sliding clamp for the DNA damage checkpoint Proceedings of the National Academy of Sciences of the United States of America. ,vol. 100, pp. 2249- 2254 ,(2003) , 10.1073/PNAS.0437148100
Eisuke Itakura, Kaori Kajihara Takai, Kazuyuki Umeda, Makoto Kimura, Mariko Ohsumi, Katsuyuki Tamai, Akira Matsuura, Amino-terminal domain of ATRIP contributes to intranuclear relocation of the ATR-ATRIP complex following DNA damage. FEBS Letters. ,vol. 577, pp. 289- 293 ,(2004) , 10.1016/J.FEBSLET.2004.10.026
Randal S Tibbetts, David Cortez, Kathryn M Brumbaugh, Ralph Scully, David Livingston, Stephen J Elledge, Robert T Abraham, Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress Genes & Development. ,vol. 14, pp. 2989- 3002 ,(2000) , 10.1101/GAD.851000