Oral microbiota dysbiosis and its association with Henoch-Schönlein Purpura in children.

摘要: Abstract Background The pathogenesis of microbes in allergic diseases has been demonstrated and our previous research indicates that microbiota causing gut disorders children is associated with Henoch-Schonlein Purpura. However, the role oral Purpura remains unknown. Method A total 164 were enrolled, which 98 patients HSP 66 healthy children. Oral swab samples collected for DNA extraction 16S rRNA gene sequencing, then analyzed composition. Results differed between those HSP. Children exhibited higher microbial diversity richness than controls. Firmicutes, Proteobacteria, Bacteroidetes are dominant phyla We used linear discriminant analysis (LDA) effect size (LEfSe) algorithm detected 21 bacterial taxonomic clades showing statistical differences (12 increased 9 decreased) correlation analyses clinical data abundance community indicated an Butyrivibrio sp. negatively correlated length hospital stay (LOS). Haemophilus to IgE IgM but positively LOS, decreasing significantly Prevotella IgM. nanceiensis IgA, abundant Conclusions These results indicate have different compared Although this study does not imply causality, it helpful identify types pathways bacteria can be prevent or treat