Gene Therapy in Lung Transplantation: Feasibility ofEx VivoAdenovirus-Mediated Gene Transfer to the Graft
作者： Alain Chapelier , Claire Danel , Michel Mazmanian , Emile A. Bacha , Hassan Sellak
DOI: 10.1089/HUM.1996.7.15-1837
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摘要: ABSTRACT Lung transplantation is associated with complications such as reperfusion injury and graft rejection. Gene therapy targeted to the offers a promising approach prevention of these complications. Because adenovirus vectors can transfer genes in vivo lung vasculature, we evaluated feasibility adenovirus-mediated gene porcine model left allotransplantation. Following removal donor lung, an vector encoding β-galactosidase (β-Gal) was injected ex into lumen upper lobe pulmonary artery graft. After 2 hr incubation at 10°C, implanted recipient animal. Three days later, animals were sacrificed for β-Gal activity. No activity detected lower used control. In contrast, endothelial cells circulation, also observed airway a...
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