Gene transfer to facilitate transplantation

摘要: Other chapters in this volume have focused on gene transfer approaches for inhibition of immune responses against autoantigens. This chapter will discuss treatment inflammatory directed alloantigens, as a result allogeneic transplantation solid parenchymal organs or dispersed cells. From an immunological standpoint, autoimmunity and alloimmunity share many the same basic mechanisms lymphocyte activation recruitment, reliance clonal nonclonal receptors to mediate cellular communication, participation cytokines adhesion diverse aspects function, effector involving CD4+ CD8+ T cells, B cells macrophages [1]. The major difference between two types is that histocompatibility complex (MHC) antigens are responsible vast majority alloresponses, while most part involves non-MHC antigens. Functional consequences these differences MHC can be presented directly class I II allorestricted respectively, processed MHC-derived peptides represented indirectly self-restricted, alloreactive In contrast, autoantigens usually context self MHC, often II, autoreactive While clearly protean nature enormous significance understanding control responses, they not resulted clinically applicable experimental practical molecular interventions substantially differentiate affect one type response preference other. As result, considerations germane equally autoimmunity.