Weight change and sulfonylurea therapy are related to 3 year change in microvascular function in people with type 2 diabetes.

摘要: Although cardiovascular disease is the biggest cause of death in people with diabetes, microvascular complications have a significant impact on quality life and financial burden disease. Little known about progression dysfunction early stages type 2 diabetes before occurrence clinically apparent complications. We aimed to explore determinants endothelial-dependent -independent function over 3 year period, without both few clinical Demographics were collected 154 participants further 99 diabetes. Skin endothelium-dependent response iontophoresis acetylcholine endothelium-independent responses sodium nitroprusside measured using laser Doppler fluximetry. All assessments repeated 3 years later. People had impaired compared those (AUC 93.9 [95% CI 88.1, 99.4] vs 111.9 [102.3, 121.4] arbitrary units [AU] × min, p < 0.001, for respectively). Similarly, endothelial-independent attenuated (63.2 [59.2, 67.2] 75.1 [67.8, 82.4] AU respectively, p = 0.002). Mean declined groups similar degree (pinteraction 0.74 0.69 nitroprusside). In use sulfonylurea was associated greater decline (p = 0.022 after adjustment co-prescriptions, change HbA1c weight), whereas improving glycaemic control less (p = 0.03). Otherwise, The principal determinant whole population weight 3 years, such that lost ≥5% very little either or stable, who gained (change 1.2 −13.2, 15.7] min weight; −15.8 [−10.5, −21.0] stable −37.8 [−19.4, −56.2] gain; ptrend < 0.001). This association endothelial driven by diabetes; relationship nonsignificant. Over physiological greatest predictor function.