In vivo near-infrared and Cerenkov luminescence imaging of amyloid-β deposits in the brain: a fluorinated small molecule used for dual-modality imaging.
作者： Hualong Fu , Cheng Peng , Zhigang Liang , Jiapei Dai , Boli Liu
DOI: 10.1039/C6CC06995A
关键词:
摘要: Three fluorinated (19F or 18F) small molecules were evaluated as fluorescent radiolabeled probes for Aβ deposits in the brain. In vivo near-infrared imaging suggested that probe 4c could efficiently distinguish between transgenic mice and wild-type controls. Furthermore, Cerenkov luminescence with [18F]4c showed modest differences two groups.
sci-hub.se 参考文章(22)
Kaixiang Zhou, Hualong Fu, Liang Feng, Mengchao Cui, Jiapei Dai, Boli Liu, The synthesis and evaluation of near-infrared probes with barbituric acid acceptors for in vivo detection of amyloid plaques. Chemical Communications. ,vol. 51, pp. 11665- 11668 ,(2015) , 10.1039/C5CC03662C
Y. Xu, H. Liu, Z. Cheng, Harnessing the Power of Radionuclides for Optical Imaging: Cerenkov Luminescence Imaging The Journal of Nuclear Medicine. ,vol. 52, pp. 2009- 2018 ,(2011) , 10.2967/JNUMED.111.092965
Robin S. Dothager, Reece J. Goiffon, Erin Jackson, Scott Harpstrite, David Piwnica-Worms, Cerenkov Radiation Energy Transfer (CRET) Imaging: A Novel Method for Optical Imaging of PET Isotopes in Biological Systems PLoS ONE. ,vol. 5, pp. e13300- ,(2010) , 10.1371/JOURNAL.PONE.0013300
Daniel L J Thorek, Anuja Ogirala, Bradley J Beattie, Jan Grimm, Quantitative imaging of disease signatures through radioactive decay signal conversion Nature Medicine. ,vol. 19, pp. 1345- 1350 ,(2013) , 10.1038/NM.3323
Mengchao Cui, Masahiro Ono, Hiroyuki Watanabe, Hiroyuki Kimura, Boli Liu, Hideo Saji, Smart near-infrared fluorescence probes with donor-acceptor structure for in vivo detection of β-amyloid deposits. Journal of the American Chemical Society. ,vol. 136, pp. 3388- 3394 ,(2014) , 10.1021/JA4052922
Hongjuan Tong, Kaiyan Lou, Wei Wang, Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer's disease Acta Pharmaceutica Sinica B. ,vol. 5, pp. 25- 33 ,(2015) , 10.1016/J.APSB.2014.12.006
Khalid Shah, Ralph Weissleder, Molecular optical imaging: applications leading to the development of present day therapeutics. Neurorx. ,vol. 2, pp. 215- 225 ,(2005) , 10.1602/NEURORX.2.2.215
Hualong Fu, Mengchao Cui, Peiyu Tu, Ziwei Pan, Boli Liu, None, Evaluation of molecules based on the electron donor–acceptor architecture as near-infrared β-amyloidal-targeting probes Chemical Communications. ,vol. 50, pp. 11875- 11878 ,(2014) , 10.1039/C4CC04907A
Hongguang Liu, Gang Ren, Zheng Miao, Xiaofen Zhang, Xiaodong Tang, Peizhen Han, Sanjiv S. Gambhir, Zhen Cheng, Molecular Optical Imaging with Radioactive Probes PLOS ONE. ,vol. 5, ,(2010) , 10.1371/JOURNAL.PONE.0009470
Yanping Yang, Mengchao Cui, Radiolabeled bioactive benzoheterocycles for imaging β-amyloid plaques in Alzheimer's disease European Journal of Medicinal Chemistry. ,vol. 87, pp. 703- 721 ,(2014) , 10.1016/J.EJMECH.2014.10.012