The synthesis and evaluation of near-infrared probes with barbituric acid acceptors for in vivo detection of amyloid plaques.

作者: Kaixiang Zhou , Hualong Fu , Liang Feng , Mengchao Cui , Jiapei Dai

DOI: 10.1039/C5CC03662C

关键词:

摘要: A new array of near-infrared probes containing barbituric acid acceptors has been developed as Aβ imaging agents. These displayed long-emission wavelengths and large Stokes shifts, well high affinities for aggregates. In vivo ex studies demonstrated that BBTOM-3 could intensely label plaques in the brains transgenic mice.

参考文章(19)
Youssef Zaim Wadghiri, Dung Minh Hoang, Thomas Wisniewski, Einar M. Sigurdsson, In Vivo Magnetic Resonance Imaging of Amyloid-β Plaques in Mice Methods in Molecular Biology. ,vol. 849, pp. 435- 451 ,(2012) , 10.1007/978-1-61779-551-0_30
Nobuyuki Okamura, Masanori Mori, Shozo Furumoto, Takeo Yoshikawa, Ryuichi Harada, Satoshi Ito, Yosuke Fujikawa, Hiroyuki Arai, Kazuhiko Yanai, Yukitsuka Kudo, In vivo Detection of Amyloid Plaques in the Mouse Brain using the Near-Infrared Fluorescence Probe THK-265 Journal of Alzheimer's Disease. ,vol. 23, pp. 37- 48 ,(2011) , 10.3233/JAD-2010-100270
John Hardy, Alzheimer's disease: the amyloid cascade hypothesis: an update and reappraisal. Journal of Alzheimer's Disease. ,vol. 9, pp. 151- 153 ,(2006) , 10.3233/JAD-2006-9S317
C. C. Rowe, V. L. Villemagne, Brain Amyloid Imaging The Journal of Nuclear Medicine. ,vol. 52, pp. 1733- 1740 ,(2011) , 10.2967/JNUMED.110.076315
Zhi-Ping Zhuang, Mei-Ping Kung, Alan Wilson, Chi-Wan Lee, Karl Plössl, Catherine Hou, David M. Holtzman, Hank F. Kung, Structure−Activity Relationship of Imidazo[1,2-a]pyridines as Ligands for Detecting β-Amyloid Plaques in the Brain Journal of Medicinal Chemistry. ,vol. 46, pp. 237- 243 ,(2003) , 10.1021/JM020351J
Mengchao Cui, Masahiro Ono, Hiroyuki Watanabe, Hiroyuki Kimura, Boli Liu, Hideo Saji, Smart near-infrared fluorescence probes with donor-acceptor structure for in vivo detection of β-amyloid deposits. Journal of the American Chemical Society. ,vol. 136, pp. 3388- 3394 ,(2014) , 10.1021/JA4052922
Hualong Fu, Mengchao Cui, Peiyu Tu, Ziwei Pan, Boli Liu, None, Evaluation of molecules based on the electron donor–acceptor architecture as near-infrared β-amyloidal-targeting probes Chemical Communications. ,vol. 50, pp. 11875- 11878 ,(2014) , 10.1039/C4CC04907A
Chongzhao Ran, Xiaoyin Xu, Scott B. Raymond, Brian J. Ferrara, Krista Neal, Brian J. Bacskai, Zdravka Medarova, Anna Moore, Design, synthesis, and testing of difluoroboron derivatized curcumins as near infrared probes for in vivo detection of amyloid-β deposits Journal of the American Chemical Society. ,vol. 131, pp. 15257- 15261 ,(2009) , 10.1021/JA9047043
Milan Klikar, Filip Bureš, Oldřich Pytela, Tomáš Mikysek, Zdeňka Padělková, Alberto Barsella, Kokou Dorkenoo, Sylvain Achelle, N,N′-Dibutylbarbituric acid as an acceptor moiety in push–pull chromophores New Journal of Chemistry. ,vol. 37, pp. 4230- 4240 ,(2013) , 10.1039/C3NJ00683B
Vasilis Ntziachristos, Jorge Ripoll, Lihong V Wang, Ralph Weissleder, Looking and listening to light: the evolution of whole-body photonic imaging Nature Biotechnology. ,vol. 23, pp. 313- 320 ,(2005) , 10.1038/NBT1074