Synthesis and evaluation of styrylpyran fluorophores for noninvasive detection of cerebral β-amyloid deposits.
作者： Bi-yue Zhu , Yan Cheng , Guo-bo Li , Sheng-yong Yang , Zhi-rong Zhang
DOI: 10.1016/J.BMC.2016.01.004
关键词:
摘要: The development of amyloid-specific fluorophores allows the visualization cerebral β-amyloid deposits using optical imaging technology. In present study, a series smart styrylpyran with compact donor-acceptor architecture were designed and evaluated for noninvasive detection deposits. Spectral behavior changed significantly (optical turn-on) upon binding to aggregates. Computational studies conducted correlate experimental Kd values calculated energies, speculating relationship between fluorophore structure affinity. vivo demonstrated that PAD-2 could discriminate APP/PS1 transgenic mice from wild type controls, specific labeling confirmed by ex observation. Collectively, these provide new scaffold probes targeting
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