Transdifferentiation of Peripheral Blood Mononuclear Cells into Epithelial-Like Cells

摘要: Bone marrow-derived stem cells have the potential to transdifferentiate into unexpected peripheral cells. We hypothesize that circulating bone might capacity epithelial-like and release matrix metalloproteinase-1-modulating factors such as 14-3-3σ for dermal fibroblasts. characterized a subset of blood mononuclear (PBMCs) develops an profile. Our findings show these develop morphology express keratin-5, -8 early day 7 21, respectively. When compared with control, conditioned media collected from PBMCs in advanced differentiation (cultures on days 28, 35, 42) increased metalloproteinase-1 expression fibroblasts (P ≤ 0.01). The depletion by immunoprecipitation reduced effect 39.5% value, 0.05). Therefore, releasable PBMC-derived is involved this process. provide new insights PBMC transdifferentiation generate subsequently will disclose therapeutic alternatives different clinical settings.