Pyridine analogues of the antimetastatic Ru(III) complex NAMI-A targeting non-covalent interactions with albumin.
作者： Michael I. Webb , Ryan A. Chard , Yaser M. Al-Jobory , Michael R. Jones , Edwin W. Y. Wong
DOI: 10.1021/IC202029E
关键词:
摘要: A series of pyridine-based derivatives the antimetastatic Ru(III) complex imidazolium [trans-RuCl4(1H-imidazole)(DMSO-S)] (NAMI-A) have been synthesized along with their sodium-ion compensated analogues. These compounds characterized by X-ray crystallography, electron paramagnetic resonance (EPR), NMR, and electrochemistry, goal probing noncovalent interactions human serum albumin (hsA). EPR studies show that choice ligands compensating ions does not strongly influence rates ligand exchange processes in aqueous buffer solutions. By contrast, rate formation persistence complexes hsA is found to be dependent on properties axial ligands. The stability binding shown correlate anticipated ability various pyridine interact hydrophobic domains hsA. prevent oligomerization solution...
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