Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3.
作者： Marta Chesi , Elena Nardini , Leslie A. Brents , Evelin Schröck , Thomas Ried
DOI: 10.1038/NG0797-260
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摘要: Dysregulation of oncogenes by translocation to the IgH locus (14q32) is a seminal event in the pathogenesis of B-cell tumours 1 . In multiple myeloma (MM), translations to the IgH locus …
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M Taniwaki, K Nishida, T Takashima, H Nakagawa, H Fujii, T Tamaki, C Shimazaki, S Horiike, S Misawa, T Abe, Nonrandom chromosomal rearrangements of 14q32.3 and 19p13.3 and preferential deletion of 1p in 21 patients with multiple myeloma and plasma cell leukemia. Blood. ,vol. 84, pp. 2283- 2290 ,(1994) , 10.1182/BLOOD.V84.7.2283.2283
JL Lai, M Zandecki, JY Mary, F Bernardi, V Izydorczyk, M Flactif, P Morel, JP Jouet, F Bauters, T Facon, Improved cytogenetics in multiple myeloma: a study of 151 patients including 117 patients at diagnosis Blood. ,vol. 85, pp. 2490- 2497 ,(1995) , 10.1182/BLOOD.V85.9.2490.BLOODJOURNAL8592490
M. K. Webster, D. J. Donoghue, Constitutive activation of fibroblast growth factor receptor 3 by the transmembrane domain point mutation found in achondroplasia. The EMBO Journal. ,vol. 15, pp. 520- 527 ,(1996) , 10.1002/J.1460-2075.1996.TB00384.X
D.M. Ornitz, P Leder, Ligand specificity and heparin dependence of fibroblast growth factor receptors 1 and 3. Journal of Biological Chemistry. ,vol. 267, pp. 16305- 16311 ,(1992) , 10.1016/S0021-9258(18)42001-7
M Chesi, PL Bergsagel, LA Brents, CM Smith, DS Gerhard, WM Kuehl, Dysregulation of cyclin D1 by translocation into an IgH gamma switch region in two multiple myeloma cell lines. Blood. ,vol. 88, pp. 674- 681 ,(1996) , 10.1182/BLOOD.V88.2.674.BLOODJOURNAL882674
Allouche M, Basic fibroblast growth factor and hematopoiesis. Leukemia. ,vol. 9, pp. 937- 942 ,(1995)
M K Webster, P Y D'Avis, S C Robertson, D J Donoghue, Profound ligand-independent kinase activation of fibroblast growth factor receptor 3 by the activation loop mutation responsible for a lethal skeletal dysplasia, thanatophoric dysplasia type II. Molecular and Cellular Biology. ,vol. 16, pp. 4081- 4087 ,(1996) , 10.1128/MCB.16.8.4081
Marta Chesi, P. Leif Bergsagel, W. Michael Kuehl, Leslie A. Brents, Selective expression of one c-myc allele in two human myeloma cell lines. Cancer Research. ,vol. 56, pp. 4370- 4373 ,(1996)
Rita Shiang, Leslie M. Thompson, Ya-Zhen Zhu, Deanna M. Church, Thomas J. Fielder, Maureen Bocian, Sara T. Winokur, John J. Wasmuth, Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia. Cell. ,vol. 78, pp. 335- 342 ,(1994) , 10.1016/0092-8674(94)90302-6
Michael C. Naski, Qing Wang, Jingsong Xu, David M. Ornitz, Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia. Nature Genetics. ,vol. 13, pp. 233- 237 ,(1996) , 10.1038/NG0696-233