[Studies on distribution, excretion and subacute toxicity of squalane in dogs].

摘要: In the previous papers, we demonstrated, by using rats, that squalane (2,6,10,15,19,23-hexamethyltetracosane) could stimulate fecal excretion of 2,3,4,7,8-pentachlorodibenzofuran, which was regarded as most important etiologic agent yusho among PCB and PCDF congeners found in causal rice oil. We also reported that, not essentially absorbed from gastrointestinal tract, did show any appreciable side effects during 3-month treatment. present paper, have investigated distribution, subacute toxicity beagle dogs. The accounted for about 83% dose initial 2 days after administration at a single oral 1,200 mg/kg to male On day 3, mostly distributed hair skin, concentrations these tissues were decreased on 6. These results suggested administered orally but part excreted through hair. addition, into liver be eliminated rather slowly. A long-term (13-week) treatments with doses 400 mg/kg/day or female dogs, resulted accumulation level 3% (400 mg/kg) 6% (1,200 daily dose. This highest all tissues. Nevertheless, no toxic signs observed serum biochemical tests hepatic functional test groups. Therefore, accumulating liver, seem disturb physiological functions. It treatment skin played role elimination squalane. conclusion, studies give significant dogs well rats.