Vascular effects and safety of supplementation with shark liver oil in middle‑aged and elderly males

摘要: Shark liver oil (SLO) has long been used as a traditional health food, with particular benefit for vascular health, in Japan. The aim of this study was to assess the effect dietary supplementation SLO on arterial stiffness and peripheral microvascular function otherwise healthy middle-aged older males slightly increased stiffness. A randomized, double-blind, placebo-controlled, parallel design assign 41 mean age 59.0±4.0 years (range, 45-69 years) either (n=21) or placebo (n=20) treatment eight weeks. effects were assessed by cardio-ankle index (CAVI) measurement hand blood flow cutaneous tissues using laser Doppler perfusion imaging (LDPI) technique, respectively. Although magnitude changes CAVI value during eight-week intervention group did not significantly differ from that group, former associated (r=0.575, P<0.01) age. It also found LDPI values at week 8 lowered (P<0.05) compared baseline while no change observed resulting significant difference between two groups (P=0.002). Neither supplementation-related adverse side-effects nor any abnormal routine laboratory tests, including lipid profiles anthropometric haemodynamic parameters, throughout intervention. may have potential safely improve elderly males.