Embryonic signals direct the formation of tight junctional permeability barrier in the decidualizing stroma during embryo implantation.

摘要: The protection of the embryo from maternal adverse environment during early pregnancy is considered to be achieved by establishment a transitory permeability barrier created decidual cells immediately surrounding implanting embryo. Normally, polarized epithelium acts as regulating paracellular passage substances through tight junctions. expression junction proteins in uterine luminal prior implantation consistent with this idea. However, limited information available regarding nature and regulation that decidualizing stromal implantation. We show here proteins, occludin, claudin-1, zonula occludens-1 occludens-2, are all expressed physically associated primary zone forming loss adjacent epithelium. blastocyst trophectoderm appears stimulus for creation barrier, since isolated inner cell mass or artificial stimuli failed induce such barrier. Furthermore, induced normal impermeable immunoglobulin molecules. These findings suggest trophoblast-induced junctions forms temporary restricts injurious immunoglobulins