Taurine attenuates amyloid β 1–42-induced mitochondrial dysfunction by activating of SIRT1 in SK-N-SH cells

摘要: Abstract Amyloid β (Aβ) plays a critical role in the pathogenesis of Alzheimer disease (AD). Studies indicate that Aβ causes reactive oxygen species (ROS) generation, mitochondrial dysfunction and neurons loss vivo vitro. Taurine, naturally occurring β-amino acid brain, has been demonstrated to have neuroprotective properties. In present study, effects taurine on cell viability function Aβ1–42-treated SK-N-SH cells were investigated. Pretreatment significantly attenuated Aβ1–42-induced neuronal death. Similarly, suppressed mPTP opening reversed presence Aβ1–42. Additionally, intracellular Ca2+ ROS generation induced by Moreover, expression Sirtuin 1 (SIRT1) was obviously recovered cells. Our results suggest prevents activation SIRT1. This study implies is prospective additive for AD patients.