Distorted Optic Nerve Portends Neurological Complications in Infants With External Hydrocephalus.

摘要: Background: Benign external hydrocephalus (BEH) is defined by rapid increase in head circumference infancy, with neuroimaging evidence of enlarged cerebrospinal fluid (CSF) spaces. BEH was postulated to predispose subdural hematoma, neurocognitive impairments, and autism. There currently no consensus on diagnostic criteria biomarkers predict neurological sequalae. Methods: MRI-based quantitative approach used for measurement potential imaging markers related their association outcomes. We scanned 23 infants diagnosed 11 age-similar controls. Using anatomical measurements from a large sample healthy (n = 150), Z-scores were calculated classify subject's CSF spaces as (≥1.96SD mean values) or normal. Results: Subjects abnormally had significantly wider longer ON (p 0.017 p 0.020, respectively), less tortuous 0.006). deformity demonstrated high accuracy frontal subarachnoid space (AUC 0.826) interhemispheric fissure 0.833). No significant found between complications (OR 0.330, 95%CI 0.070-1.553, 0.161). However, cluster analysis identified distinct subgroup children (23/34, 67.6%) wider, ON, have an increased risk (RR 7.28, 1.07-49.40). Discussion: This the first report hydrocephalus, complications. Our findings challenge current view benign condition. auxiliary marker stratification patients