Targeted therapy for metastatic colorectal cancer

Robert J Mayer, Eric Van Cutsem, Alfredo Falcone, Takayuki Yoshino, Rocio Garcia-Carbonero, Nobuyuki Mizunuma, Kentaro Yamazaki, Yasuhiro Shimada, Josep Tabernero, Yoshito Komatsu, Alberto Sobrero, Eveline Boucher, Marc Peeters, Ben Tran, Heinz-Josef Lenz, Alberto Zaniboni, Howard Hochster, James M Cleary, Hans Prenen, Fabio Benedetti, Hirokazu Mizuguchi, Lukas Makris, Masanobu Ito, Atsushi Ohtsu, None, Randomized Trial of TAS-102 for Refractory Metastatic Colorectal Cancer The New England Journal of Medicine. ,vol. 372, pp. 1909- 1919 ,(2015) , 10.1056/NEJMOA1414325

Andrew Rowland, Mafalda M Dias, Michael D Wiese, Ganessan Kichenadasse, Ross A McKinnon, Christos S Karapetis, Michael J Sorich, Meta-analysis of BRAF mutation as a predictive biomarker of benefit from anti-EGFR monoclonal antibody therapy for RAS wild-type metastatic colorectal cancer. British Journal of Cancer. ,vol. 112, pp. 1888- 1894 ,(2015) , 10.1038/BJC.2015.325

S.Y. Brulé, D.J. Jonker, C.S. Karapetis, C.J. O’Callaghan, M.J. Moore, R. Wong, N.C. Tebbutt, Cr. Underhill, D. Yip, J.R. Zalcberg, D. Tu, R.A. Goodwin, Location of colon cancer (right-sided versus left-sided) as a prognostic factor and a predictor of benefit from cetuximab in NCIC CO.17 European Journal of Cancer. ,vol. 51, pp. 1405- 1414 ,(2015) , 10.1016/J.EJCA.2015.03.015

Filippo Pietrantonio, Chiara Cremolini, Fausto Petrelli, Maria Di Bartolomeo, Fotios Loupakis, Claudia Maggi, Carlotta Antoniotti, Filippo de Braud, Alfredo Falcone, Roberto Iacovelli, First-line anti-EGFR monoclonal antibodies in panRAS wild-type metastatic colorectal cancer: A systematic review and meta-analysis. Critical Reviews in Oncology Hematology. ,vol. 96, pp. 156- 166 ,(2015) , 10.1016/J.CRITREVONC.2015.05.016

C. Cremolini, M. Di Bartolomeo, A. Amatu, C. Antoniotti, R. Moretto, R. Berenato, F. Perrone, E. Tamborini, G. Aprile, S. Lonardi, A. Sartore-Bianchi, G. Fontanini, M. Milione, C. Lauricella, S. Siena, A. Falcone, F. de Braud, F. Loupakis, F. Pietrantonio, BRAF codons 594 and 596 mutations identify a new molecular subtype of metastatic colorectal cancer at favorable prognosis Annals of Oncology. ,vol. 26, pp. 2092- 2097 ,(2015) , 10.1093/ANNONC/MDV290

Ryan B. Corcoran, Chloe E. Atreya, Gerald S. Falchook, Eunice L. Kwak, David P. Ryan, Johanna C. Bendell, Omid Hamid, Wells A. Messersmith, Adil Daud, Razelle Kurzrock, Mariaelena Pierobon, Peng Sun, Elizabeth Cunningham, Shonda Little, Keith Orford, Monica Motwani, Yuchen Bai, Kiran Patel, Alan P. Venook, Scott Kopetz, Combined BRAF and MEK inhibition with dabrafenib and trametinib in BRAF V600-Mutant colorectal cancer Journal of Clinical Oncology. ,vol. 33, pp. 4023- 4031 ,(2015) , 10.1200/JCO.2015.63.2471

Justin Guinney, Rodrigo Dienstmann, Xin Wang, Aurélien De Reynies, Andreas Schlicker, Charlotte Soneson, Laetitia Marisa, Paul Roepman, Gift Nyamundanda, Paolo Angelino, Brian M Bot, Jeffrey S Morris, Iris M Simon, Sarah Gerster, Evelyn Fessler, Felipe De Sousa E Melo, Edoardo Missiaglia, Hena Ramay, David Barras, Krisztian Homicsko, Dipen Maru, Ganiraju C Manyam, Bradley Broom, Valerie Boige, Beatriz Perez-Villamil, Ted Laderas, Ramon Salazar, Joe W Gray, Douglas Hanahan, Josep Tabernero, Rene Bernards, Stephen H Friend, Pierre Laurent-Puig, Jan Paul Medema, Anguraj Sadanandam, Lodewyk Wessels, Mauro Delorenzi, Scott Kopetz, Louis Vermeulen, Sabine Tejpar, None, The consensus molecular subtypes of colorectal cancer Nature Medicine. ,vol. 21, pp. 1350- 1356 ,(2015) , 10.1038/NM.3967

Feriyl Bhaijee, Thomas Huebner, Ralph H. Hruban, Laura D. Wood, Nathan Cuka, Drew M. Pardoll, Nickolas Papadopoulos, Kenneth W. Kinzler, Shibin Zhou, Toby C. Cornish, Janis M. Taube, Robert A. Anders, James R. Eshleman, Bert Vogelstein, Luis A. Diaz, Dung T. Le, Jennifer N. Uram, Hao Wang, Bjarne R. Bartlett, Holly Kemberling, Aleksandra D. Eyring, Andrew D. Skora, Brandon S. Luber, Nilofer S. Azad, Dan Laheru, Barbara Biedrzycki, Ross C. Donehower, Atif Zaheer, George A. Fisher, Todd S. Crocenzi, James J. Lee, Steven M. Duffy, Richard M. Goldberg, Albert de la Chapelle, Minori Koshiji, PD-1 Blockade in Tumors with Mismatch-Repair Deficiency The New England Journal of Medicine. ,vol. 372, pp. 2509- 2520 ,(2015) , 10.1056/NEJMOA1500596

Nancy Kemeny, Ying Huang, Alfred M. Cohen, Weiji Shi, John A. Conti, Murray F. Brennan, Joseph R. Bertino, Alan D.M. Turnbull, Deidre Sullivan, Jennifer Stockman, Leslie H. Blumgart, Yuman Fong, Hepatic Arterial Infusion of Chemotherapy after Resection of Hepatic Metastases from Colorectal Cancer New England Journal of Medicine. ,vol. 341, pp. 2039- 2048 ,(1999) , 10.1056/NEJM199912303412702

Nicolas J Llosa, Michael Cruise, Ada Tam, Elizabeth C Wicks, Elizabeth M Hechenbleikner, Janis M Taube, Richard L Blosser, Hongni Fan, Hao Wang, Brandon S Luber, Ming Zhang, Nickolas Papadopoulos, Kenneth W Kinzler, Bert Vogelstein, Cynthia L Sears, Robert A Anders, Drew M Pardoll, Franck Housseau, None, The Vigorous Immune Microenvironment of Microsatellite Instable Colon Cancer Is Balanced by Multiple Counter-Inhibitory Checkpoints Cancer Discovery. ,vol. 5, pp. 43- 51 ,(2015) , 10.1158/2159-8290.CD-14-0863