Characterization of juvenile and young adult mice following induction of hydrocephalus with kaolin.

摘要: Hydrocephalus is a common neurological problem in humans, usually caused by an impairment of cerebrospinal fluid (CSF) flow or absorption. A reliable induced model chronic hydrocephalus mice would be useful to test hypotheses using genetic mutants. Our goal was characterize behavioral and histological changes juvenile young adult with kaolin (aluminum silicate)-induced hydrocephalus. Seven-day old 7-8 week received injection into the cisterna magna. Behavior assessed repeatedly. Seven 14 days following kaolin, magnetic resonance (MR) imaging used assess ventricle size. In hydrocephalic mice, body weight significantly lower than age-matched saline-injected sham controls gait posture score were impaired. Juvenile developed severe ventriculomegaly had reduced corpus callosum thickness gross white matter destruction days. Reactive astroglial change cortex cellular proliferation subependymal zone also apparent. Young only moderate ventricular enlargement without overt destruction, although there atrophy mild reaction matter. Glial fibrillary acidic protein content higher at 7 days, but myelin basic not altered. conclusion, percutaneous feasible. The associated periventricular alterations are essentially same as those reported rats comparable ages.