The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria.
作者： Teresa L M Thurston , Grigory Ryzhakov , Stuart Bloor , Natalia von Muhlinen , Felix Randow
DOI: 10.1038/NI.1800
关键词:
摘要: Cell-autonomous innate immune responses against bacteria attempting to colonize the cytosol of mammalian cells are incompletely understood. Polyubiquitylated proteins can accumulate on surface such bacteria, and bacterial growth is restricted by Tank-binding kinase (TBK1). Here we show that NDP52, not previously known contribute immunity, recognizes ubiquitin-coated Salmonella enterica in human and, binding adaptor Nap1 Sintbad, recruits TBK1. Knockdown NDP52 TBK1 facilitated proliferation increased number containing ubiquitincoated salmonella. also recruited LC3, an autophagosomal marker, knockdown impaired autophagy We conclude utilize ubiquitin system activate their cytosol.
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