Corneal collagen crosslinking for keratoconus and corneal ectasia: One-year results

摘要: PURPOSE:Toevaluate 1-yearoutcomes of cornealcollagencrosslinking(CXL) fortreatment keratoconus and corneal ectasia. SETTING: Cornea refractive surgery subspecialty practice. DESIGN: Prospective randomized controlled clinical trial. METHODS:Collagen crosslinking was performed in eyes withkeratoconus orectasia. Thetreatment group received standard CXL the sham control riboflavin alone. Principal outcomes included uncorrected (UDVA) corrected (CDVA) distance visual acuities, refraction, astigmatism, topography-derived maximum average keratometry (K) value. RESULTS: The UDVA improved significantly from 0.84 logMAR G 0.34 (SD) (20/137) to 0.77 0.37 (20/117) (P Z .04) CDVA, 0.35 0.24 (20/45) 0.23 0.21 (20/34) (P<.001). Fifteen patients (21.1%) gained 1 patient lost (1.4%) 2 or more Snellen lines CDVA. K value decreased baseline by 1.7 3.9 diopters (D) (P<.001), 2.0 4.4 D .002), 1.0 2.5 .08) entire cohort, subgroup, ectasia respectively. 22 (31.0%) increased 3 (4.2%). CONCLUSIONS: Collagen effective improving UDVA, value, Keratoconus had improvement topographic measurements than with Both CDVA worsened between month, followed 1, 3, 6 months stabilization thereafter.